Long-term use of melatonin supplements to support sleep may have negative health effects

Long-term Melatonin Use Linked to Health Risks

A review of five years of health records for over 130,000 adults with insomnia who used melatonin supplements for at least one year revealed a higher likelihood of heart failure diagnosis, hospitalization for heart failure, and increased mortality from any cause in those with chronic insomnia.

Study Presentation and Context

This preliminary study is set to be presented at the American Heart Association’s Scientific Sessions 2025, held from November 7-10 in New Orleans. The event is a leading global forum for the latest advances in cardiovascular science and evidence-based clinical updates.

Melatonin Background

Melatonin is a hormone produced naturally by the pineal gland, which regulates the sleep-wake cycle. Its levels rise during darkness and fall with daylight.

Supplement Use and Regulation

Synthetic melatonin, chemically identical to the natural hormone, is widely used as an over-the-counter supplement to treat insomnia and jet lag in many countries, including the United States.

“In the U.S., over-the-counter supplements do not require government approval to ensure quality and consistency, so each brand of supplement can vary in strength, purity, etc.”

Health Warnings

Despite its popularity, this study suggests that prolonged melatonin supplementation for sleep disorders may carry significant health risks, particularly related to heart health.

Author’s Summary: Extended use of melatonin supplements to manage insomnia may increase risks of heart failure and mortality, highlighting the need for caution and further research.

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www.heart.org www.heart.org — 2025-11-04

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