NFL Picks and Predictions for Week 6
The NFL season continues with a highly-anticipated slate of games in Week 6. Here are 3 plus-money bets to consider before kickoff.
By Spenser Davis, published on Oct 12, 2025.
Introduction to Week 6 NFL Picks
Last week's NFL bold predictions went 2-1, resulting in a gain of +1.17 units. Since Week 3, the picks in this story have accumulated a total of +2.16 units.
Week 6 Bold Predictions
- Fading the Colts offense may not be the wisest choice, but there is a case for doing so.
Indianapolis is currently averaging 3.39 points per drive, which would be the highest this century if they maintain this pace all season long.
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Author's summary: NFL Week 6 plus-money bets and predictions.